Anti-inflammatory and Pain-Relieving Action (CB2 and TRPV1): The CB2 receptor , abundant on immune cells, is the main target for CBD's anti-inflammatory action, crucial for calming the chronic inflammation underlying many gynecological conditions . Simultaneously, TRPV1 (vanilloid receptor), involved in the transmission of burning and pain, is modulated to reduce hypersensitivity and allodynia, essential in conditions such as vulvodynia and cystitis.

Modulation of Stress and Muscle Tension (5-HT1A, GABA, Glycine): CBD interacts with the serotoninergic 5-HT1A receptor , helping to mitigate anxiety and tension, especially in the pelvic floor. Modulation of GABA and glycine receptors facilitates relaxation and improves sleep quality, acting as an indirect support for stress-related hormonal balance.

Metabolic and Antioxidant Support (PPARγ): The PPARγ receptor is critical for glucose and lipid metabolism. CBD activation helps reduce oxidative stress and may improve insulin sensitivity and hyperinsulinemia, a key aspect of PCOS.

How FIR works: FIR energy stimulates the production of Nitric Oxide (NO) , a powerful vasodilator that improves microcirculation and tissue oxygenation.

The Synergistic Benefit: Applied to the pelvic floor, the FIR Pad reduces venous congestion and tissue hypoxia , which often fuel chronic pain.

By improving blood flow, the FIR Pad increases the tissue absorption of CBD, whether taken topically or transdermally, amplifying its anti-inflammatory and regenerative effects.

Localized Benefit: They allow an effective concentration of CBD to act directly on the nerve receptors in the area, addressing the inflammation and pain typical of cystitis, candidiasis, and vulvodynia, without having to be metabolized by the body.

Areas of Application: They are particularly indicated for the relief of chronic pelvic pain , dyspareunia (pain during intercourse), post-infectious or post-menstrual irritation and vaginal dryness.

Tolerability: They offer an anti-inflammatory and regenerating effect, without altering the delicate vaginal pH or interfering with the beneficial bacterial flora, a crucial aspect for avoiding recurrences.

Chronic Stress and Hypercortism: Persistent stress increases cortisol (the stress hormone) levels, which in turn worsens insulin resistance . This triggers a vicious cycle in which excess insulin stimulates the ovaries to produce excessive androgens, worsening symptoms.

Diet and Inflammation: A high intake of refined sugars and high-glycemic carbohydrates triggers constant insulin spikes, directly fueling hyperandrogenism and systemic inflammation.

Nutritional Deficiencies and Insomnia: Deficiencies of key nutrients such as Vitamin D (an essential steroid hormone) and poor sleep quality destabilize the hormonal axis and metabolic response.

Taking Contraceptives Without a Metabolic Strategy: Although the pill is an effective treatment for masking symptoms (regular periods, reduced androgens), it does not correct the underlying metabolic cause, namely insulin resistance . Stopping the pill without first correcting the metabolic cause almost always leads to a rapid relapse of symptoms.

Crash or Restrictive Diets: Crash or overly severe diets increase metabolic stress and cortisol levels, paradoxically making weight loss more difficult and worsening insulin sensitivity.

Stimulant Abuse: Excess caffeine or other stimulants can exacerbate adrenal stress and anxiety, negatively affecting hormonal balance.

Foods to Avoid (Low Glycemic Load): It is essential to eliminate high glycemic index foods such as refined sugars , white flours (non-whole grain bread, pasta, rice), processed sweets , and alcohol . Processed dairy products are often discouraged due to their high content of growth factors that can mimic hormones.

Foods to Favor (Anti-inflammatory Focus): The diet should favor sources of antioxidants and Omega-3:

Effective Physical Activity: The most effective exercises are those that improve insulin sensitivity, particularly resistance training (weights, strength exercises) which increases muscle mass (the main consumer of glucose) and moderate aerobic exercise (brisk walking, light jogging, yoga/Pilates) for stress management.

CBD Support and Stress: CBD isolate (taken sublingually or transdermally) is a crucial support.
Its anxiolytic action reduces cortisol, stabilizing hormonal tone, while the activation of the PPAR$\gamma$ receptor helps improve insulin sensitivity, facilitating weight loss.

CBD Modulation: CBD , through its action on the PPAR$\gamma$ and GPR55 receptors, helps regulate glucose metabolism and reduce ovarian inflammation, promoting hormonal rebalancing without the suppression typical of contraceptives.

Key Supplements (Non-Drug):

Physical Synergy: The combination of CBD with the FIR Pad applied to the pelvic floor promotes lymphatic drainage and the reduction of ovarian congestion, supporting the regression of cysts over time.

PureOil CBD 30% in flaxseed oil or MCT → modulates HPA axis and insulin sensitivity, reduces androgens.

Terpenes: limonene, caryophyllene, linalool → regulate CB2, PPARγ and TRPV1, reducing ovarian inflammation.

CBD ovules (vaginal use) → local action on pelvic inflammation and ovarian pain.

FIR Pelvic Pad (20–30 min) → stimulates NO and improves ovarian microcirculation.

Vitamin D3 + K2 patches → modulate insulin sensitivity and sex hormones.

Reduction of ovarian inflammation and pelvic pain

Better hormonal balance and cycle regularity

Increased insulin sensitivity and reduction of acne/unwanted hair

Improved fertility and general well-being

Complex Etiology: The main cause is chronic inflammation of the nerve endings (often branches of the pudendal nerve) following trigger events (e.g. recurrent candidiasis, trauma, pelvic muscle hypertonicity).

The nervous system permanently records these stimuli as dangerous.

Clinical Manifestations: The patient experiences allodynia (pain to the touch), hyperalgesia (pain out of proportion to the stimulus) and constant or intermittent burning , especially in the vaginal vestibule (vestibulodynia), which make sexual activity (dyspareunia) and the use of tight clothing extremely difficult.

Cardinal Symptoms:

Diagnosis (Exclusion Test): The diagnosis is based on a specialist clinical evaluation which includes the performance of:

CBD Ovules and FIR Pad Therapy:

Anti-inflammatory Strategies: We recommend using CBD isolate suppositories or creams to control local symptoms, combined with sublingual administration to manage stress and systemic pain. Additionally, supplementing with vitamin D3, magnesium, and omega-3 is crucial for supporting nerve membrane health and reducing systemic neuroinflammation.

PureOil CBD 30% in sesame or flaxseed oil → improves microcirculation and parasympathetic tone, reducing hyperexcitability of the pudendal nerve.

Terpenes: myrcene, linalool, beta-caryophyllene → act on TRPV1, GABA and CB2 reducing pain and hypersensitivity.

CBD ovules (vaginal use) → analgesic, decongestant and regenerative effect on vaginal nerve endings.

FIR Pelvic Pad (20–30 min) → stimulates nitric oxide and reduces pelvic venous congestion.

24h CBD Patches → continuous control of nervous hyperactivity and central pain.

Reduction of vulvar pain and burning

Improved microcirculation and vagal tone

Neurovegetative calm and pelvic relaxation

Reduction of venous congestion and nociplastic pain

Triggering Factors: The use of antibiotics (which destroy protective Lactobacilli ), diets high in sugar (the fuel for the fungus), chronic stress, hormonal imbalances and prolonged use of the contraceptive pill are the main factors that destabilize the microbiota.

Cardinal Symptoms: Intense itching , burning during urination and intercourse, thick white discharge (similar to cottage cheese) and persistent redness .

CBD Modulating Approach: Isolated CBD is not a direct antifungal , but works by regulating the local immune response (via CB2), reducing the excessive vaginal inflammation that accompanies infections. This action is crucial for soothing intense itching and allowing beneficial flora to repopulate the environment.

Anti-Relapse Protocol: The combination of CBD suppositories (for their soothing and anti-inflammatory action), a strictly low-sugar diet, and supplementation with targeted probiotics is the key to restoring healthy flora and preventing relapses.

Signs of Regression: As the candida regresses, symptoms begin to diminish: itching and burning decrease, discharge returns to normal, and redness disappears.

CBD Microbiota Support: CBD supports the vaginal environment indirectly: by reducing inflammation, it helps restore a more acidic pH and strengthens endogenous defenses. By modulating the immune system's CB2 receptors, CBD counteracts the excessive inflammatory reaction that makes the area vulnerable to fungal recurrences.

Main Symptoms: Burning during urination (dysuria), continuous and urgent urge to urinate (urgency), suprapubic pain and, sometimes, cloudy urine.

Immediate Remedies: For rapid relief, it's essential to drink plenty of fluids to dilute urine and reduce bacterial load. Taking preparations containing D-mannose hinders bacterial adhesion. Using CBD isolate (sublingual drops or suppositories) can quickly act on pain and inflammation receptors, calming the acute attack.

Reduction of Bladder Inflammation (CB2 and TRPV1): CBD calms inflammation of the bladder wall, reducing the sensitization of nerve endings (less pain and less urge to urinate).

Decreased Urgency (5-HT1A): Acts on the anxiety component and on the tension of the detrusor muscle, thanks to the interaction with serotonin receptors, reducing bladder hyperactivity.

Over-the-counter medications and supports: D-mannose (to prevent E. coli from adhering), vaginal and oral probiotics (to restore the flora), and anti-inflammatories (NSAIDs, to relieve symptoms).

FIR Pad and Hydration: Applying the FIR Pad to the lower abdomen stimulates blood circulation, promoting the drainage of inflammatory cells. Consistent use of CBD isolate (sublingual and suppositories), combined with abundant hydration and these supports, is key to the lasting resolution of recurrent cystitis, avoiding the excessive use of medications that damage the microbiota.

Reduction of burning and urinary urgency

Anti-inflammatory and soothing action on the bladder mucosa

Improved pelvic microcirculation

Support for the urogenital microbiota

Natural prevention of relapses without altering the flora

Calms the autonomic nervous system that controls the bladder

PCOS: Hormonal balance and metabolic improvement.

Vulvodynia: Reduction of neurogenic pain and chronic inflammation.

Candida and Cystitis: Restores local immune defenses and reduces inflammation.

Visit our Online Shop 

Read also the other articles on our blog

Join our Facebook Group to stay up to date.

Follow our Agrilab Facebook page

Follow our A grilab Instagram page 

Contact us for any questions or clarifications on our Whatsapp number +393471103543

Read reviews from those who have already tried our products