CBD isolate for endometriosis: a complete guide to symptoms, diagnosis, and natural treatments.

By Isabella TortaNovember 04, 2025

cbd isolato per endometriosi la guida completa agrilab

What is endometriosis: causes to recognize

What is endometriosis?

Endometriosis is a chronic, progressive inflammatory disease in which cells similar to those that line the inside of the uterus ( endometrium ) are found outside the uterine cavity, in abnormal locations such as the ovaries, fallopian tubes, peritoneum, bladder, or intestine.

These ectopic endometrial cells respond to the same hormones as the menstrual cycle each month: they thicken, shed, and bleed. However, because they cannot exit the body as normal menstrual flow does, they cause internal microbleeding, inflammation, pain, and the formation of scar tissue (adhesions) .

Over time, these endometrial lesions can invade nearby organs, alter the mobility of pelvic organs, compromise bowel and urinary function, and cause chronic pain even in the absence of menstruation.

Endometriosis is a multisystem and underestimated disease, often confused with “painful menstruation” and therefore diagnosed years late.

Causes of endometriosis: why do we get it?

The causes of endometriosis are not yet fully understood, but a multifactorial origin is recognized. The main factors involved include:

Genetic and epigenetic factors : There is a higher incidence in women with affected first-degree relatives.
Immune system dysfunction : The body does not recognize the misplaced endometrial cells as abnormal and does not eliminate them.
Hormonal changes , particularly excess estrogen or an imbalance between estrogen and progesterone.
Chronic systemic inflammation : Endometriosis is now considered a fully-fledged inflammatory disease.
Imbalances in the intestinal and vaginal microbiota : Recent studies show that an alteration in the bacterial flora can influence inflammation and the immune response.

The combination of these factors leads to a persistent inflammatory response , which releases mediators such as prostaglandins, cytokines, and interleukins.
These activate and sensitize pain receptors, creating a condition of visceral hyperalgesia and central sensitization , responsible for many symptoms even outside the menstrual period.

At what age does it manifest itself?

Endometriosis can appear as early as adolescence , often in the form of severe dysmenorrhea (very painful menstruation), but in most cases it is diagnosed between the ages of 25 and 40 , in full childbearing age.

The main problem is that many girls and women live with intense pain without receiving a diagnosis, because menstrual pain is still too often normalized or underestimated .

On average, 7-10 years pass between the onset of the first symptoms and the definitive diagnosis, a delay that can worsen the progression of the disease and the quality of life.

How the body changes due to endometriosis

Endometriosis is not just a disease of the reproductive system, but a systemic condition that affects many bodily functions:

Immune system : the inflammatory response is altered, with constant production of pro-inflammatory mediators.
Autonomic nervous system : an imbalance is created between the sympathetic (fight/flight) and parasympathetic (rest/repair) systems, with reduced vagal activation.
Intestinal system : Many patients develop irritable bowel syndrome, constipation or diarrhea, persistent bloating, and sometimes subblockages.
Musculoskeletal system : Adhesions form that alter posture and cause pelvic or lumbar muscle pain.
Neuroendocrine system : Chronic stress associated with illness can affect hormone production, mood, and sleep quality.

The body enters a constant low-grade inflammatory state , with chronic neuropathic pain, persistent fatigue, mood swings, anxiety, insomnia , and altered body perception.

What happens to those who suffer from endometriosis?

Those suffering from endometriosis often experience disabling pain that extends beyond menstruation. Pelvic pain can become continuous and involve:

sexual intercourse (dyspareunia),
bowel movements (painful defecation),
urination,
posture and gait.

It is often associated with pelvic venous congestion , abdominal swelling , a feeling of heaviness and constant tension in the lower abdominal area.

From a psychological and functional point of view, many women report:

anxiety and panic attacks ,
changes in appetite (or emotional binges),
extreme tiredness ,
reduction in sleep quality ,
decreased sexual desire ,
difficulty concentrating and brain fog .

All of this has a profound impact on the quality of life , work and relationships.
It is essential that the condition is recognized and treated not only as a gynecological disorder , but as a multisystem and neuroinflammatory disease.

Endometriosis symptoms: the main ones to recognize

The main symptoms include chronic pelvic pain, severe dysmenorrhea, abdominal bloating, pain during intercourse, fatigue, and intestinal disorders.
During outbreaks, nausea, mild fever, cramps, and lower back pain may occur. Many women notice a swollen belly that varies with their menstrual cycle.

What are the symptoms of an endometriosis outbreak?

An endometriosis focus is a small accumulation of endometrial tissue (similar to that lining the uterus) found in abnormal locations, such as the ovaries, intestines, peritoneum, or bladder. Even if small, it can cause very significant symptoms, because endometriosis doesn't depend on the size of the lesion, but on its location and the inflammatory response it triggers .

Typical symptoms of an outbreak include:

Localized pelvic pain , even if intermittent
Very intense menstrual cramps , often not proportional to the cycle
Pain during intercourse (dyspareunia)
Back pain or rectal pain during menstruation
Irregular bleeding or spotting
Digestive or urinary problems , if the outbreak is near the bladder or intestine

⚠️ Even a single outbreak can cause chronic inflammation and alter the quality of life.

What are the symptoms of stage 2 endometriosis?

Endometriosis is classified into 4 stages (I to IV) according to the American Society for Reproductive Medicine, based on:

Number and size of outbreaks
Presence of adhesions
Ovarian involvement

Stage II is considered a mild form, with deeper lesions than stage I and possible micro-adhesions.

Symptoms are often similar to those of more advanced stages, because the severity of the symptoms does not always correspond to the severity of the disease .

Common symptoms of stage II:

Severe and persistent menstrual cramps
Pain during or after intercourse
Chronic fatigue
Pain during bowel movements or urination during menstruation
Difficulty conceiving , if the ovaries or tubes become involved

Isolated CBD, in these cases, can help reduce pain and inflammation by acting on receptors such as CB1, CB2, TRPV1, GPR55 and PPARγ , also modulating the perception of pain at a central level.

How do you know if you have endometriosis?

Understanding if you suffer from endometriosis is not always easy , because the symptoms can be confused with other disorders such as irritable bowel syndrome, recurrent cystitis or “normal” menstrual cramps.

Here are some signs you shouldn't ignore :

Disabling menstrual pain (that doesn't go away with common painkillers)
Chronic pelvic pain , even outside of your period
Pain during intercourse or after orgasm
Feeling of bloating and heaviness in the abdomen , sometimes called “endometriosis belly”
Abnormal bleeding or premenstrual spotting
Cyclic urinary or bowel problems (constipation, diarrhea, urgency to urinate, pain)

📋 The definitive diagnosis is obtained with tests such as transvaginal ultrasound , magnetic resonance imaging and, in doubtful cases, with exploratory laparoscopy.

💡 CBD isolate, used as a natural support, can help reduce inflammation, rebalance the autonomic nervous system, and improve mood , offering a complementary strategy without interfering with the hormonal cycle.

Endometriosis and a bloated belly: what's the difference?

How to recognize an endometriosis belly?

The so-called "endometriosis belly" is a very common and often overlooked symptom: it manifests as marked abdominal swelling , which can appear cyclically or remain constant. Women describe it as a hard, taut, visibly swollen belly , especially in the lower abdomen.

Typical signs:

Bloating that gets worse before or during your period
Abdomen visibly protruding and painful to pressure
Sensation of internal pressure or pelvic heaviness
Possible association with constipation, flatulence or diffuse abdominal pain

Many women report that, during those days, “ it feels like being 4-5 months pregnant .”

Why does endometriosis cause swelling?

Abdominal swelling associated with endometriosis is caused by a combination of factors:

Chronic inflammation : Ectopic endometrial tissue causes a continuous release of inflammatory cytokines , which increase vascular permeability and cause edema and swelling.
Intestinal involvement : If endometriosis affects the rectum or intestines, it can alter motility and cause bloating, spasms, and cyclical digestive disturbances .
Pelvic congestion : slow venous return can generate a sensation of pressure and persistent swelling .
Autonomic nervous system dysfunction : Endometriosis alters the sympathetic-parasympathetic balance, compromising peristalsis and digestion.

🧠 Isolated CBD can be a valuable ally: by acting on receptors such as TRPV1, GPR55, CB2 and chemokine receptors , it helps reduce inflammation and pain, normalizing the response of the enteric nervous system (the intestinal “second brain”) and also improving intestinal motility.

How does the abdomen change with endometriosis?

Over time, endometriosis can alter not only the function of the pelvic organs, but also the appearance and sensation of the abdomen :

Swollen, hard, asymmetrical abdomen
Chronic tenderness on palpation
Appearance of adhesions that pull on the internal tissues, causing persistent discomfort or sudden twinges
In severe cases, there may be difficulty in digestion , a feeling of early fullness, changes in intestinal frequency

📌 Swelling is not just aesthetic : it is a warning sign of an ongoing inflammatory process and neurovascular congestion .

CBD isolate for endometriosis: therapy with ovules and FIR pads

CBD for endometriosis: why it's a safe choice

CBD isolate is a pure molecule, free of THC and legal (THC < 2 ppm).

It is a safe choice because it does not act on the brain like a drug , but intelligently modulates inflammation, pain and mood receptors.

Unlike hormonal drugs, it does not alter estrogen levels and does not interfere with fertility.

Its goal is not to block the symptom, but to restore the biological balance (homeostasis) between the nervous, immune and hormonal systems.

CBD isolate for endometriosis: how it works

CBD isolate for endometriosis interacts with over 65 molecular targets .
In endometriosis, the main mechanisms involved are:

· CB1 and CB2 – reduce inflammation and neuropathic pain;

· TRPV1 – regulates the perception of pelvic pain;

· 5-HT1A – improves anxiety and mood;

· PPARγ – inhibits the production of pro-inflammatory cytokines;

· GPR55 – reduces the proliferation of ectopic endometrial tissue;

· GABA and glycine receptors – relax pelvic muscles and reduce spasms;

· Estrogen receptors and calcium channels – rebalance the hormonal response and reduce painful contraction.

Furthermore, CBD promotes peripheral vasodilation and microcirculation, useful in cases of pelvic congestion .

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CBD suppositories for endometriosis: their role in pelvic pain

Vaginal suppositories with CBD isolate represent one of the most effective and natural solutions for deep pelvic pain. They act locally , penetrating the mucous membranes and reaching receptors in the urogenital area.

The main benefits are:

· immediate reduction of pain and muscle tension

· direct anti-inflammatory action on tissues

· improvement of microcirculation

· rebalancing of the vaginal flora .

Used cyclically, they can reduce the frequency of painful outbreaks and improve sexuality.

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The FIR Pad for Endometriosis: The Role of Far Infrared Rays

The FIR Pad (Far Infrared Pad) uses far infrared ray technology (4–16 µm) , a form of energy that penetrates the tissues and stimulates the endogenous production of nitric oxide (NO) .
NO is a vasodilatory molecule that:

· improves blood flow

· reduces pelvic venous congestion

· modulates inflammation ,

· promotes the release of serotonin and dopamine .

In cases of endometriosis, applying the FIR Pad to the abdomen or lower back helps to decongest the tissues and relieve visceral pain .

Biological synergy between CBD isolate and FIR Pad

The combination of CBD isolate + FIR Pad works on two fronts:

· CBD regulates receptors and reduces neurohormonal inflammation ,

· the FIR Pad increases tissue bioavailability and stimulates circulation.

Together, they enhance nitric oxide production, improve cellular metabolism, and reduce pain sensitivity.

This approach is known as “4-Step Therapy” AgriLab’s modulating therapy that includes CBD + FIR , ideal for those looking for long-lasting and natural results without side effects.

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Agrilab FIR pad heat pad for pain treatment of endometriosis

Why THC is not recommended for endometriosis

Although medical cannabis is sometimes prescribed to relieve endometriosis pain, it is important to distinguish the sedative effect of THC from a true therapeutic modulating effect.
THC (tetrahydrocannabinol), the main psychoactive component of cannabis, does not physiologically modulate inflammation and can interfere with the delicate neuroimmune balance typical of a disease like endometriosis.

Here are the main reasons why THC is not recommended:

Psychoactive effect : THC acts directly and powerfully on the CB1 receptor, altering perception, memory, and mood. This can exacerbate anxiety, derealization, and feelings of disconnection, especially in patients who are already emotionally or hormonally fragile.
Tolerance induction : Regular THC intake leads to desensitization of the CB1 receptors , requiring increasingly higher doses to achieve the same effect. This increases the risk of addiction and a loss of effect over time .
Parasympathetic nervous system deregulation : Endometriosis is associated with an imbalance between the sympathetic (fight/flight) and parasympathetic (rest and recovery) nervous systems. THC can inhibit vagal regulation , worsening anxiety, insomnia, and autonomic changes.
Interference on GABA and glutamate : While CBD positively modulates GABA (inhibitory neurotransmitter), THC can alter its balance, promoting neuronal hyperactivity, insomnia, agitation and worsening central sensitization.
Effects on the microbiota : Recent studies suggest that THC may negatively alter the intestinal flora and intestinal permeability , a crucial factor in the context of endometriosis, where the microbiota plays a key role in the immune response and chronic inflammation.
Masking, not curative effect : THC can temporarily mask pain, but does not affect the specific receptors that modulate inflammation, nociception, and altered neurotransmission typical of endometriosis.

In conclusion, THC does not represent a modulating therapy , but a temporary sedative with potential medium-long term side effects.

In contrast, isolated CBD works intelligently and selectively on over 65 molecular targets , modulating the systems involved in the disease (pain receptors, inflammation, GABA, serotonin, glutamate, TRPV1, cytokine and immune receptors) without causing tolerance, addiction or cognitive alterations .

For this reason, CBD isolate is currently the safest, most physiological, and sustainable approach to managing endometriosis symptoms.

Tests and diagnosis for endometriosis

What tests are available to determine if you have endometriosis?

Diagnosing endometriosis can be difficult , because the symptoms are often confused with other conditions (such as IBS, cystitis, recurrent vaginitis).
Early diagnosis is essential to avoid chronicity and permanent damage .

The main diagnostic tools are:

Transvaginal ultrasound (with or without specific probe)
Pelvic MRI to locate deep or intestinal implants
Diagnostic laparoscopy : it is the only test that confirms with certainty the presence of endometriosis (and can also remove the foci)

👩⚕️ The average diagnostic delay in Italy is still 7–9 years. This delay can be reduced with greater awareness and a dedicated support network .

How is the diagnosis of endometriosis confirmed?

A definitive diagnosis of endometriosis is achieved through diagnostic laparoscopy , a minimally invasive surgical procedure that allows for direct visualization of endometriotic lesions within the pelvis and, in many cases, their removal during the same procedure.

However, before arriving at laparoscopy, non-invasive tests are performed that can guide the clinical suspicion:

Transvaginal ultrasound with a specific probe , useful for identifying ovarian cysts (endometriomas) or deep nodules
Pelvic MRI , indicated in case of suspected deep intestinal, bladder or uterosacral endometriosis
Gynecological physical examination , to evaluate stiffness, localized pain and abnormalities of the cervix or ligaments

📍 Important: No blood test (such as CA-125) is sufficient to confirm or exclude endometriosis, as there is no specific biological marker for the disease.

💡 Clinical note: The diagnostic delay is still high (up to 9 years on average): many women receive incorrect diagnoses (irritable bowel syndrome, vaginitis, recurrent cystitis) or are minimized.
It is essential to rely on specialized endometriosis centers with gynecologists experienced in reading the indirect signs of the disease.

Living with endometriosis: complications and quality of life

What problems can endometriosis cause?

Endometriosis is a chronic inflammatory disease that can cause a wide range of physical, hormonal and psychological problems , also affecting quality of life and fertility.

Here are the main problems it can cause:

Chronic pain

Pelvic : even away from the cycle
During menstruation (dysmenorrhea) : often unbearable
During intercourse (dyspareunia) : can compromise intimacy
During defecation or urination : especially in cases of intestinal or bladder endometriosis

Infertility

Endometriosis can alter pelvic anatomy, create adhesions, damage the ovaries, or prevent ovulation. It is a leading cause of female infertility .

Systemic inflammation and chronic fatigue

The constant presence of inflamed tissue stimulates the immune system, causing fatigue, muscle pain, and a persistent feeling of exhaustion.

Digestive and urinary disorders

Abdominal swelling, colic, constipation or cyclical diarrhea
Constant urge to urinate, recurrent cystitis, bladder pain

Psychological problems

Living with chronic pain, infertility, or painful sexual intercourse can lead to:
- Anxiety and depression
- Sleep disorders
- Loss of self-esteem and social isolation

💡 Important note: Endometriosis is not just a gynecological disease , but a systemic problem, which can affect the intestines, bladder, diaphragm, pelvic nerves and even the immune system.

For this reason, many women rely on an integrated approach, not just pharmacological , which includes:

Natural anti-inflammatory therapies
CBD isolate to modulate pain and inflammation
Anti-inflammatory diet
Treatments to improve venous return and reduce pelvic congestion (such as the FIR Pad )

Endometriosis and fertility: what to know

Endometriosis is a leading cause of female infertility. However, being diagnosed with endometriosis doesn't automatically mean you won't be able to have children . Each case is different, and today there are many natural, medical, and integrative solutions to address the problem.

Can people with endometriosis have children?

Yes, many women with endometriosis are able to have children , even without resorting to IVF. However, the likelihood may vary depending on:

Degree and location of the disease
Age of the woman
Presence of ovarian adhesions or cysts
Function of the tubes and endometrium

In some cases, endometriosis can make conception more difficult , but it does not rule it out entirely.

Does endometriosis affect fertility?

Yes, it can compromise fertility , but not in all patients.

Here's how:

It can damage the ovaries , reducing ovarian reserve.
It can alter the normal functioning of the tubes , preventing the passage of the egg.
It causes a chronic inflammatory state , which can compromise the implantation of the embryo in the uterus.
Adhesions between organs can hinder conception or cause ectopic pregnancies.

Endometriosis treatment: available therapies and solutions

💡 Our integrated approach is based on three pillars that can naturally help improve fertility in patients with endometriosis:

How is endometriosis treated?

Endometriosis treatment is neither unique nor definitive . Each woman's clinical history is different, and treatment must be adapted to the severity of the disease, age, symptoms, and fertility goals .

The main strategies are:

Hormone therapies (conventional)

Doctors often prescribe:

Combined birth control pill
Progestins (e.g. Dienogest)
GnRH analogues (pharmacological menopause induction)

🔴 These therapies don't cure the disease but temporarily halt its progression. They often have significant side effects : weight gain, mood swings, insomnia, depression, and osteopenia.

What is endometriosis surgery?

The most commonly used procedure is diagnostic-operative laparoscopy , a minimally invasive procedure that allows for both definitive diagnosis and treatment.

During the operation the surgeon can:

Remove endometriotic foci
Remove adhesions
Remove ovarian cysts (endometriomas)
Free the tubes and the organs involved

📌 Goal of surgery : reduce pain, improve fertility, and restore pelvic anatomy.

⚠️ Caution: Even after surgery, endometriosis can recur . For this reason, it is essential to combine it with a natural anti-inflammatory and preventative protocol .

Alternative solutions

CBD isolate: a natural anti-inflammatory

It works by modulating inflammation without altering the hormonal axis.
It reduces pelvic pain and improves quality of life , supporting a possible path to conception.
It interacts with specific receptors (CB2, TRPV1, PPARγ) linked to inflammation, fertility and tissue regeneration.

🛑 THC is strongly discouraged , because:

It may interfere with ovulation
It reduces the quality of oocytes
It has documented negative effects on the endometrium

FIR Pad: support for pelvic microcirculation

Far infrared rays (4–16 μm) stimulate microcirculation and venous return , promoting the elimination of inflammatory cytokines.
This effect can relieve pelvic congestion and improve the uterine environment.

Diet and lifestyle

An anti-inflammatory diet rich in omega-3s, magnesium, and antioxidants can improve ovulation and uterine microbiota.
Avoid refined gluten, industrial dairy products and sugars , which increase systemic inflammation.

Endometriosis: How to Interpret the Signs of Healing

When does endometriosis go away?

Endometriosis does not go away on its own , nor is there currently a definitive cure . However, in some natural conditions such as:

pregnancy
menopause
or thanks to effective integrated treatments, clinical remission of symptoms can be achieved even for long periods.

⚠️ It is important to distinguish between the disappearance of symptoms and the disappearance of the disease : even in the absence of pain, silent lesions or adhesions may persist.

Can endometriosis be eliminated?

Surgically, some foci can be removed, but:

it is not always possible to eliminate all the implants
Recurrences are common (up to 40% within 5 years)
surgery does not eliminate the chronic inflammatory basis of the disease

💡 For this reason, a comprehensive therapeutic approach is essential, which reduces systemic inflammation and modulates the immune response.

Am I cured of endometriosis?

Many women write to us: “I feel healed. Is it possible?”
The most correct answer is:

🟡 If your symptoms are gone or greatly reduced , you are in clinical remission .

But be careful:

The disease can reactivate in the presence of hormonal imbalances , stress , infections , inflammatory diet
It is not a "cure" in the absolute sense, but an effective and long-lasting management

📌 Remission is not a miracle. It is the result of constant, consistent, and personalized therapy.

Legal aspects and patient support

Are those suffering from endometriosis entitled to Law 104?

Yes, those suffering from endometriosis may be entitled to the benefits provided by Law 104 , but only in some specific cases , when the disease is recognised as severely disabling .

When does endometriosis qualify for 104?

Recognition of Law 104/1992 depends on:

Recognized degree of disability (at least 74% is required for some employment and social security benefits)
Impact of symptoms on daily and working life
Presence of complications (such as severe adhesions, chronic disabling pain, impairment of the reproductive or intestinal organs)

What do you have to do to get it?

Submit an application to INPS , attaching a detailed medical certificate from a specialist (gynecologist, endometriosis center, ultrasound, MRI, etc.)
Facing a visit with the medico-legal commission
If recognized, you can access:
- Work permits
- Tax breaks
- Caregiver protections (if the person needs assistance)

🔎 Remember:

Endometriosis has been officially recognized by the Ministry of Health as a chronic and disabling disease since 2023.
However, not all forms automatically give access to Law 104 : precise clinical documentation and a serious symptomatic picture are required.

💡 Practical advice: If you believe your condition falls into the severe category, you can seek help from a patient association or a CAF/Patronato ( healthcare assistance center) in completing the INPS application.

Endometriosis is recognized in Italy as a chronic disabling disease

(Ministry of Health Table, 2023).

Patients can access:

Exemptions for visits and medications (exemption code G93)
Work permits and benefits (Law 104 if the situation is serious)
Benefits for civil disability (in case of severe forms)

🤝 AgriLab offers a free personalized support service : we help you understand:

Which natural therapies can complement or replace conventional treatments?
How to modulate inflammation and pain without hormones
How to approach the legal recognition process of the disease

Conclusion

Endometriosis is a complex but manageable disease.

The natural and scientifically based approach with CBD isolate, CBD vaginal suppositories and FIR Pad today represents a new frontier in the integrated treatment of pelvic pain and chronic inflammation .

It's not about covering up a symptom, but about restoring the neuro-hormonal and microcirculatory balance .

CBD isolate modulates receptors and calms the body; the FIR Pad reactivates circulation and nitric oxide; together they restore harmony, energy, and well-being.

Find out how CBD Isolate can help with various conditions.

👉 Keep following us on the blog : in the next articles we will talk about all the pathologies that can be supported by CBD isolate.

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