Evidence is still preliminary but encouraging. A retrospective study of 121 patients published in Pharmacotherapy (Rhyne et al., 2016) observed a reduction in the average attack frequency from 10.4 to 4.6 per month in those using medical cannabis; however, the study concerned cannabis as a whole and not isolated CBD. At a preclinical level, more recent reviews (Russo et al., 2024) describe how cannabinoids can modulate CB1/CB2 receptors and neurogenic inflammation related to CGRP, the main mediator of migraine pain. Randomized clinical trials on humans specifically for isolated CBD are still lacking, so it should be understood as a complementary support to the treatment path followed with one's doctor, not as a substitute. Interplay between cannabinoids and the neuroimmune system in migraine, PMC 2024.

There is no universal dosage: a prudent approach involves starting with 2 sublingual drops in the morning and evening for the first 3 days, then moving to 3 drops morning, afternoon, and evening from the fourth day, holding the oil under the tongue for 60-90 seconds before swallowing. Our team offers a free consultation to personalize the dosage and product combination based on your case.

It depends on the need and they are often combined: the oil acts systemically and is indicated for daily support and in the acute phase, transdermal CBD patches offer localized and continuous release if applied to the neck and nape, the FIR Pad acts with the heat of far infrared rays to relax cervical muscles, while magnesium patches support the prevention of crises in the long term. Many customers combine them, following the usage instructions provided in this guide.

Isolated CBD, free of THC and phytocomplex, reduces the risk of contaminants and undesirable reactions compared to full-spectrum or FECO products, which are often less regulated, offering superior purity and greater dosage control.

Tension headache is the most common form: pressure pain, bilateral, of mild or moderate intensity, often linked to stress, incorrect posture, or dehydration. Migraine, on the other hand, is a throbbing pain, generally unilateral, of moderate or severe intensity, often accompanied by nausea and photophobia, with a greater impact on daily activities. ISSalute.it.

The evidence here is weaker compared to migraines. In the only study published on the subject (Leroux et al., 2013, Cephalalgia, 139 patients with cluster headache), only 27 had tried cannabis specifically for attacks: 25.9% reported perceived efficacy, 51.8% variable or uncertain effects, and 22.3% negative effects. This is not a result that allows for solid conclusions, and it concerned cannabis as a whole, not isolated CBD. Those suffering from cluster headaches should discuss any complementary support with their neurologist, maintaining their prescribed therapy. Leroux et al., "Use of cannabis among 139 cluster headache sufferers", Cephalalgia 2013.

No, they are not the same thing: cannabis contains THC, the psychoactive principle, while AgriLab products use isolated CBD, free of THC. AgriLab products are derived from industrial hemp compliant with Law 242/2016 (THC within 0.2%). The Court of Justice of the European Union has established that CBD has no psychotropic effects and cannot be classified as a narcotic substance (case C-663/18, November 19, 2020). An attempt by the Ministry of Health to include oral CBD compositions among narcotics is currently suspended by the Council of State, awaiting clarification from the EU Court of Justice (Quotidiano Sanità, 2026).

Yes, and it's important to know before starting. CBD is metabolized by cytochrome P450 enzymes and can alter blood levels of various medications: anticoagulants like warfarin, some antiepileptics (sometimes also used in migraine prophylaxis) and some antidepressants, among others. If you are taking prescribed medications, particularly for the prevention of migraine or cluster headache, always talk to your doctor or pharmacist before starting, and never change an ongoing therapy on your own initiative. Hill et al., "Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol", Journal of General Internal Medicine 2021.